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| AYAHUASCA
"Ayahuasca is like a bus tour of Paris museums for several hours. Smoked N,N-DMT is the same tour, but strapped to the nose of a rocket, and everything goes by in 10 minutes. Smoked 5-MeO-DMT is like being strapped to the nose of a rocket that flies into the sun and evaporates." -Bob Wallace The traditional Ayahuasca brews of South America contain 2 main ingredients; the bark of the Banisteriopsis caapi vine and the leaves of the Psychotria viridis. Today, Ayahuasca can mean any combination of plants that contain DMT plus an MAOI. The effects of Ayahuasca can last 4-8 hours, depending on the amount of MAOI consumed. As DMT in of itself is not active orally, it needs another ingredient to make it active; this is where MAOI's comes in. How the natives of South America found this combination, with tens of thousands of plants in the Amazon to choose from is incredible. The "I" in MAOI stands for "inhibitor" and an MAO inhibitor is what allows the DMT drug to become orally active. The following excerpt is found on page 69, from a great body of work titled, "The Spirit Molecule" by Dr. Rick Strassman; he better explains the AYAHUASCA-DMT-MAOI effect. "The pineal gland contains the necessary building blocks to make DMT. For example, it possesses the highest levels of serotonin anywhere in the body, and serotonin is a crucial precursor for pineal melatonin. The pineal also has the ability to convert serotonin to tryptamine, a critical step in DMT formation.
The unique enzymes that convert serotonin, melatonin, or tryptamine into psychedelic compounds also are present in extraordinarily high concentrations in the pineal. These enzymes, the methyltransferases, attach a methyl group—that is, one carbon and three hydrogens—onto other molecules, thus methylating them. Simply methylate tryptamine twice, and we have di-methyl-tryptamine, or DMT. Because it possesses the high levels of the necessary enzymes and precursors, the pineal gland is the most reasonable place for DMT formation to occur. Surprisingly, no one has looked for DMT in the pineal. The pineal gland also makes other potentially mind-altering substances, the beta-carbolines. These compounds inhibit the breakdown of DMT by the body's monoamine oxidases (MAO). One of the most striking examples of how beta-carbolines work is ayahuasca. Certain plants that contain betacarbolines are combined with other plants that contain DMT to make this psychedelic Amazonian brew, which allows the DMT to become orally active. If it weren't for the beta-carbolines, MAO in the gut would rapidly destroy this swallowed DMT, and it would have no effect on our minds."
Illustration showing the location of the pineal gland |
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